Title:
Proteinmicrocapsulesintegratedhierarchicalscaffoldsforlocaltreatmentofacutemyocardialinfarctionmodel
Authors:FanyiHuang
LingyuSun
ChengZhao
ZepingQiu
YuanjinZhao
WeiJin
Highlights:Productionofanovelproteinmicrocapsulesintegratedhierarchicalscaffold.
Enhancingthebioavailabilityandstabilityofangiotensinconvertingenzyme2.
Improvingadverseremodelingaftermyocardiuminfarctionandintrathoracicadhesion.
Proposalapotentiallocalnon-invasivesustainabledrugdeliverymode.
Abstract:
Asaseverecardiovasculardisease,acutemyocardialinfarction(AMI)hasbeenattachingincreasingattentionandresearchforitshighmorbidityandmortality.Inthispaper,thenovelproteinmicrocapsulesintegratedhierarchicalscaffoldisdesignedfortreatingAMImodelbyusingmicrofluidictemplates.Basedonadvancedmicrofluidicelectrospraytechnique,core-shellmicrosphereswithcontrollablesizearefabricatedtobuildadoublebarrierforimprovingthestabilityofencapsulateddrug.Thesemicrospheresarefurther
